Ambrettolide

Ambrettolide (CAS #28645-51-4), also known as 15-Hexadecanolide or Exaltolide 16, is a premium synthetic macrocyclic musk lactone highly prized in the fragrance and cosmetics industries for its refined, musky aroma and exceptional fixative properties156.
Key Features
Chemical Formula: C₁₆H₃₀O₂
Molecular Weight: 254.41 g/mol
EC Number: 249-091-0
Appearance: Colorless to pale yellow liquid or oil
Odor Profile: Soft, musky, ambrette-like with subtle fruity, rosy, and pear nuances; considered one of the most elegant and natural-smelling synthetic musks15.
Synonyms
Hexadecanolide
Exaltolide 16
Ambrettolactone
Isoambrettolide
Oxacycloheptadec-10-en-2-one
Applications
Perfumery:
Ambrettolide is a key ingredient in high-end fine fragrances, valued for its luxurious, musky scent and outstanding fixative power. It enhances longevity and depth in floral, musky, and oriental compositions, and is especially effective in trace amounts to boost radiance and roundness in blends1.
Cosmetics:
Used in creams, lotions, deodorants, and body mists to impart a soft, elegant fragrance and elevate the sensory experience of personal care products26.
Aromatherapy:
Appreciated for its calming, grounding qualities, adding a warm, musky character to therapeutic blends.
Home Fragrance:
Commonly found in candles, diffusers, and room sprays for its rich, long-lasting scent and ability to create a luxurious ambiance1.
Technical & Regulatory Information
Biodegradability: Readily biodegradable with low bioaccumulation risk, making it suitable for environmentally conscious formulations1.
IFRA Compliance: Permitted in fragrances according to current IFRA standards, with no specific restrictions1.
REACH Registered: Approved for use in perfumery and cosmetic formulations13.
Safety: Non-sensitizing in standard patch testing; not classified as hazardous or as a substance of very high concern (SVHC)14.
Food Use: FEMA 4145; approved for use in flavor applications at controlled levels5.
Storage & Handling
Storage Conditions: Store in a cool, dry, well-ventilated area, away from heat, light, and direct sunlight. Refrigeration is recommended for long-term storage47.
Shelf Life: 24 months under recommended storage conditions4.
Handling Precautions: Avoid contact with eyes and skin; use personal protective equipment and ensure good ventilation. Do not ingest or inhale concentrated vapors47.
Ambrettolide stands out as one of the finest and most elegant synthetic musks, delivering a soft, naturalistic musk character and exceptional performance in both fine fragrance and personal care applications